The Problem
A silent epidemic affecting over 30 million people, representing half of all heart failure cases.
Prognosis is grim, with a 5-year mortality rate (~50%) worse than many cancers.
Frequently misdiagnosed as normal aging, leading to delayed and ineffective treatment.
Treatment Limitations
A major unmet clinical need with few therapies that fundamentally alter the disease.
Current treatments mostly manage symptoms (like fluid overload) instead of the root cause: a stiff heart muscle.
Proven drugs for other types of heart failure have consistently failed in large-scale HFpEF trials.
Patient Impact
Debilitating breathlessness makes simple daily tasks exhausting.
Creating a "shrinking world" of lost independence, social isolation, and depression.
Patients live in constant fear of sudden flare-ups, leading to frequent, traumatic hospitalizations.